Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor
Fig 3
Antiviral treatment of symptomatic cats with FIP.
(A) In two independent studies, cats were inoculated with FIPV at day 0 and GC376 treatment was started after they developed lymphopenia and clinical symptoms. In the 2nd study, cats received supportive treatment for five days (shaded boxes), which was discontinued prior to antiviral treatment. The arrows and forward slashes indicate antiviral treatment duration and euthanasia, respectively. dpi, days post infection. (B-D) Responses of cats with FIP to antiviral treatment: body temperature (B), percent body weight changes (C) and lymphocyte counts (D) over time. The shaded areas indicate the normal range of values. Colored arrows located between panels B and D indicate the treatment duration for each cat.