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Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance

Fig 6

Interferon-α resistance of TF and NT viruses.

(A) Spearman correlation of the replication measured by area under the curve (AUC) (y-axis) of each tested variant (black dots) and the replication (AUC) in the presence of interferon alpha (x-axis) (Non-parametric Spearman p < .0001, r = 0.8844). (B) Virus growth over 10 days in culture as measured by reverse transcriptase (RT) activity (DLU = digital light units) of the TF (blue), and NT variants (red) in the presence of IFN-α (dotted) and absence of IFN-α (solid lines) in an example pair 331. (C) RC scores in the presence of IFN-α were divided by the RC score in the absence of IFN-α for TF (blue) and selected NT (red) viruses with similar replication kinetics (Wilcoxon matched-pairs signed rank test, two tailed, p = 0.219). Subtype B TF (blue) and 6-month consensus (red) viruses are shown as controls on the right.

Fig 6

doi: https://doi.org/10.1371/journal.ppat.1005154.g006