Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance
(A) Neutralization of TF (blue) and NT (red) IMC by donor plasma was measured for each pair in a TZM-bl neutralization assay. Percent neutralization by donor plasma (diluted 1:100) is depicted on the y-axis, and representative TF and NT viruses tested for each transmission pair are depicted on the x-axis. The median of the NT variants is designated with a black line. The statistical significance of the difference between TF and NT donor median values was determined using a two-tailed Wilcoxon matched-pairs signed rank test (p = 0.031). (B) Spearman correlation of the pairwise distance to the amino acid subtype C consensus and donor plasma neutralization described in part A over all the variants tested from 6 transmission pairs (p = 0.011, r = -0.4995).