Heterosexual Transmission of Subtype C HIV-1 Selects Consensus-Like Variants without Increased Replicative Capacity or Interferon-α Resistance
The pairwise distance of each viral variant on the (A) nucleotide and (B) amino acid phylogenetic trees to the LANL subtype C consensus node were measured and plotted for each transmission pair. Transmitted/founder variants are in blue, and non-transmitted variants are in red. The median of the non-transmitted variants is designated with a black line. The statistical significance of the difference between TF and NT donor median values was analyzed using a one-tailed Wilcoxon matched-pairs signed rank test.