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Parallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)

Fig 5

Average fractional methylation levels in different gene regions.

A) Average Fractional Methylation level for 1kbp upstream of coding region, first 500bp of first 6 exons, first 500bp of first 5 introns and 1kbp downstream of coding region are shown in the figure. B) Average Fractional Methylation level for 1kbp upstream of coding region, first 3kbp of protein coding region and 1kbp downstream of coding region are shown in the figure. In this figure, the x-axis is the relative coordinate with a word size of 20bp. The y-axis is the average fractional methylation level of CpGs of all genes in a 20bp word (detailed in Materials and Methods). The black line represents the average fractional methylation level for methylated genes in control and the blue line represents the average fractional methylation level for methylated genes in treatment. The red line represents the average fractional non-methylation level for non-methylated genes in control and orange line represents the average fractional methylation level for non-methylated genes in treatment.

Fig 5

doi: https://doi.org/10.1371/journal.ppat.1004713.g005