Parallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)
A) The 753 differentially expressed genes were compared to the set of canonical immune genes identified in the genome by Evans et al (2006). Only 19 genes were shared between these groups B) The differentially expressed genes were compared to genes differentially regulated in response to infection with E. coli and the microsporidian parasites Nosema apis and Nosema ceranae. There was little overlap among the groups, indicating that responses to acute viral infections utilize distinct pathways. C) Overlap with three previous studies examining transcriptional responses to Sindbis virus, IAPV (from Chen et al, 2014), and DWV. For all analyses, the Venn diagram was created using Venny.