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Parallel Epigenomic and Transcriptomic Responses to Viral Infection in Honey Bees (Apis mellifera)

Fig 1

Viral infection with IAPV alters gene expression patterns in honey bee fat bodies.

A) A volcano plot was created to visualize the amount of significantly differentially expressed genes. The horizontal line represents an FDR p-value of 0.05 and the vertical lines represent a two-fold change in the log of the expression. The red circles indicate genes that are significantly differentially expressed in response to viral infection. 753 genes were found to be significantly differentially expressed (FDR <0.05). B) A heat map of the log 2 transformed read counts for the 753 significantly differentially expressed genes was generated. Transcription levels were normalized using a TMM method. Red colors indicate higher levels of gene expression and blue colors indicated lower levels of gene expression relative to the average across the samples. Treatment and control samples are denoted by “TMT” and “CTL” respectively. The heat map was created with R statistical software.

Fig 1

doi: https://doi.org/10.1371/journal.ppat.1004713.g001