Unravelling Human Trypanotolerance: IL8 is Associated with Infection Control whereas IL10 and TNFα Are Associated with Subsequent Disease Development
Figure 4
Box-plots of IL10, TNFα, and IL8 concentrations measured in the plasma of SERO TL+ subjects at study inclusion according to follow-up results.
SERO TL+/HAT: individuals confirmed as HAT patients (n = 12); SERO TL+/CATTneg individuals with decreasing CATT responses with end titers becoming <1/8 (n = 15); SERO TL+/CATT≥1/8: individuals maintaining elevated CATT responses with end titers ≥1/8 (n = 13). Significant differences in cytokine levels are indicated (**: 0.01<p<0.001; *: 0.05<p<0.01) for a group in comparison with the two others (nonparametric Wilcoxon signed-rank test).