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Dynamics of HIV Latency and Reactivation in a Primary CD4+ T Cell Model

Figure 6

Reactivating agents fail to provide cellular environment necessary for completion of HIV life cycle.

Each panel summarizes over-represented pathways among the differentially expressed genes induced by the indicated treatment. Organized under ten major categories, each individual circle represents one enriched pathway in Reactome (see methods). The size is proportional to the adjusted p-value (q-value), and the y-axis corresponds to the average effect of the differentially expressed genes within the reported pathway. Only TCR stimulation using anti-CD3/CD28 and IL-2 leads to upregulation of numerous cellular pathways, as well as upregulation of reported HIV cofactors and HIV related pathways (shown in red). AZA is not shown as no enrichment was observed.

Figure 6

doi: https://doi.org/10.1371/journal.ppat.1004156.g006