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The Contribution of Viral Genotype to Plasma Viral Set-Point in HIV Infection

Figure 1

The estimated node effect plotted onto the phylogeny.

The estimated phylogenetic effect of each node on log10 viral load plotted back onto the phylogeny from the 652-sample BEAST analysis. The axis shows the time in years from the most recent sequence, which was taken in 2009. Branches have been colored by the scale of the effect. Clusters of branches have been collapsed to improve readability, and are colored by the average tip effect within each cluster. As the number of bifurcations in the tree reduces at around 17.5 years before 2009, this used as the threshold for collapsing. Nodes that have a similar effect on viral load cluster together, as expected if some of the variation in viral load is heritable.

Figure 1

doi: https://doi.org/10.1371/journal.ppat.1004112.g001