Target Cell Availability, Rather than Breast Milk Factors, Dictates Mother-to-Infant Transmission of SIV in Sooty Mangabeys and Rhesus Macaques
Figure 4
T cell differentiation and proliferation in infant SM and RM tissues.
(A) The proportion of naïve (CD28+CD95−) and memory (CD28+/−CD95+) CD4+ T cells in lymphoid and gastrointestinal tissues of infant SMs and RMs was measured at necropsy. For each tissue site, the total may not add to 100% because of minor populations excluded in gating. (B) The level of cell activation/proliferation was measured in CD4+ T cells isolated from multiple tissues of infant RMs and SMs using the marker Ki-67. Mann-Whitney test was used to determine significance. Comparisons without p value shown were non-significant.