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Red Blood Cell Invasion by Plasmodium vivax: Structural Basis for DBP Engagement of DARC

Figure 7

Mapping polymorphic residues and inhibitory epitopes reveals targets of selective pressure.

DBP-RII molecules are in green and yellow. DARC molecules are in purple and blue. DARC residue labels are underlined. (A) Nonsynonymous DARC polymorphisms in primates, residues colored in blue, which make critical contacts with DBP-RII provide a mechanism for inter-species transmission barriers. (B) Polymorphic DBP residues, in blue, are spread throughout the molecule. The most polymorphic region of DBP is the “DEK epitope” opposite the DARC14–43 binding site. (C) Inhibitory epitopes, in red and brown, map to the heterotetramer interface, DARC binding pockets and RBC proximal face of DBP-RII.

Figure 7