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Serotonergic Chemosensory Neurons Modify the C. elegans Immune Response by Regulating G-Protein Signaling in Epithelial Cells

Figure 6

Serotonin synthesis in chemosensory neurons inhibits the immune response by altering rectal epithelial G-protein signaling.

In response to environmental cues, such as the presence or absence of food, serotonin, released from ADF chemosensory neurons acts, directly or indirectly, to regulate GOA-1(Gαo) signaling in the rectal epithelium. This signaling suppresses the Dar phenotype that forms part of the innate immune response and limits the rate of pathogen clearance from the rectal opening.

Figure 6