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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Figure 4

Selected heavy and light chain clones were paired and tested for neutralization breadth and potency on a cross-clade 6-virus panel.

(A) Heavy and light chain nodes leading to mAb PGT121 and (B) PGT124 were paired and tested on a 74-virus panel of PGT121- or PGT124-sensitive viruses. Boxes are colored by IC50 values (µg/ml) of each isolate neutralized.

Figure 4