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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Figure 3

Selected heavy and light chain clones were paired and tested for neutralization breadth and potency on a cross-clade 6-virus panel.

Neutralization breadth and potency summary of all the paired clones. The clones are arranged from least (bottom-left) to most (top-right) mutated with heavy chain listed on the left and light chain listed across the bottom. Boxes are colored according to neutralization score, which is defined as mean(log10(10/IC50)); black boxes represent pairs whose neutralization scores were not determined.

Figure 3