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The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies

Figure 1

Mutation summary of selected heavy and light chain clones.

Mutation frequency was calculated over the V-gene and J-gene as nucleotides or amino acids differing from the putative germline sequence for (A) heavy chain sequences and (B) light chain sequences. The CDR3 regions and insertions and deletions were excluded from the analysis. CDR3 lengths were determined according to the IMGT definition. Analyses were performed with the SciPy stack [53] and figures were generated using matplotlib [54] and graphviz [55].

Figure 1