A Structure-Guided Mutation in the Major Capsid Protein Retargets BK Polyomavirus
Figure 4
Carbohydrate binding sites of BKPyV, JCPyV and SV40.
Recognition of carbohydrate receptors by BKPyV (A), SV40 (B), and JCPyV (C). Only residues making direct hydrogen bonds or van der Waals interactions are shown. Residues that make conserved interactions are colored in yellow, side chains whose positions are not conserved are shown in green (BKPyV), blue (SV40) and pink (JCPyV). (D) Comparison of carbohydrate ligands of BKPyV, SV40 and JCPyV. The oligosaccharides are colored green, blue and pink for the BKPyV, SV40 and JCPyV ligands, respectively. The structures were aligned using the protein main chain.