Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection
Figure 7
Minimal impact of TLR7 and TLR9 blockade on plasma IFN-α and ISG expression.
(A) Plasma IFN-α levels were quantified by ELISA. Shown is the plasma concentration of IFN-α for each animal in untreated (n = 5) and DV056-treated (n = 4) groups as well as the means for each group. (B) Relative expression of ISG in PBMC. Shown is the expression of the indicated genes normalized to ubiquitin for each animal in untreated and DV056-treated groups as well as the means for each group over time. P values in A and B reflect differences between untreated and DV056 treated profiles. (C) Expression of the same genes in lymph nodes. Shown is the mean +/− SEM for individual genes in lymph node cell suspensions for untreated (n = 5) and DV056-treated (n = 4) macaques. P values reflect trends in gene expression over the 3 time points.