The Pharmaco –, Population and Evolutionary Dynamics of Multi-drug Therapy: Experiments with S. aureus and E. coli and Computer Simulations
Figure 6
Simulation of the population dynamics of actively replicating and persister bacteria under antibiotic treatment.
Unless otherwise noted, parameter values used for the simulations are the standard values in Table 1. (a) Clearance dynamics under single antibiotic treatment, assuming low level persistence (Amax = 0, Bmax = 10, f = 10−5, g = 10−6, ψminA = 0, ψminB = −5) (b) Clearance dynamics under dual antibiotic treatment, assuming additive drug interactions and low level persistence (f = 10−5, g = 10−6, ψminA = −5, ψminB = −5, ψminAB = −5) (c) Clearance dynamics under dual antibiotic treatment, assuming suppressive drug interactions and high level persistence (f = 10−2, g = 10−3, ψminA = −10, ψminB = −5, ψminAB = −2) (d) Clearance dynamics under dual antibiotic treatment, assuming synergistic interactions and low level persistence (f = 10−5, g = 10−6, ψminA = −10, ψminB = −5, ψminAB = −15).