Lymphotoxin Signaling Is Initiated by the Viral Polymerase in HCV-linked Tumorigenesis
Figure 3
Lymphotoxins are not deregulated either in N-myc-driven or in spontaneous liver tumors.
(A) RT-qPCR analysis of LTα, LTβ and LTβR mRNA expression in N-myc tumors and wild type mice from the same breeding. Quantification was performed on three different mice. (B) RT-qPCR analysis of LTα, LTβ and LTβR mRNA expression in spontaneous tumors. 18S RNA expression was used as a reference. (C) Western blot analysis of LTβ in spontaneous and N-myc tumors. FLN 445 tumor was used as positive control. Expression of a housekeeping gene, GAPDH, served as a loading control. Numbers identify the animals analyzed.