Advertisement

< Back to Article

Therapeutic Efficacy of Antibodies Lacking FcγR against Lethal Dengue Virus Infection Is Due to Neutralizing Potency and Blocking of Enhancing Antibodies

Figure 2

Modified MAbs targeting the fusion loop epitope prevent antibody-enhanced lethal DENV infection in relation to their neutralizing potency.

A. AG129 mice were administered a lethal dose of DENV2 D2S10 and 24 hours later were treated with 20 µg of modified MAb targeting the fusion loop (n = 3–6 per group from 2 independent experiments). See Table S2 for numbers of mice in each group. B. AG129 mice were administered an enhancing dose of polyvalent DENV1-immune mouse serum, infected with DENV2 D2S10, and 24 hours later treated with 20 µg of modified MAbs (n = 3–6 per group from 2 independent experiments). See Table S2 for numbers of mice in each group. C. AG129 mice were administered an enhancing quantity (20 µg) of 4G2 MAb, infected with DENV2 D2S10, and 24 hours later treated with 20 µg of modified MAb (n = 3–9 per group from at least 2 independent experiments). See Table S3 for numbers of mice in each group. A Kaplan-Meier survival curve is shown, and log-rank analysis was used for statistical comparison.

Figure 2

doi: https://doi.org/10.1371/journal.ppat.1003157.g002