Chemokine Receptor Ccr1 Drives Neutrophil-Mediated Kidney Immunopathology and Mortality in Invasive Candidiasis
Figure 9
Ccr1 deficiency does not decrease the expression of other neutrophil-targeted chemotactic factors or adhesion molecules in Candida-infected kidneys.
(A) Relative mRNA expression of neutrophil-targeted chemoattractant receptors in Ccr1+/+ and Ccr1−/− kidneys at day 9 after infection. (B) Relative mRNA expression of neutrophil-targeted ELR CXC chemokines in Ccr1+/+ and Ccr1−/− kidneys at day 9 after infection. (C) Relative mRNA expression of neutrophil-targeted adhesion molecules in Ccr1+/+ and Ccr1−/− kidneys at day 9 after infection. Data are from two independent experiments using nine Ccr1+/+ and eight Ccr1−/− mice.