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A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

Figure 6

S. haematobium egg-injected mice display systemic Type 2 cytokine and immunoglobulin responses.

Egg-injected mice demonstrate elevated serum levels of Type 2-associated cytokines (e.g. IL-5) with decreased or unchanged serum levels of TH1- and TH17-associated cytokines (e.g. IFN-γ and IL-17, respectively, [A]). The Type 2 bias in systemic cytokine expression parallels increased IgE production (B).

Figure 6

doi: https://doi.org/10.1371/journal.ppat.1002605.g006