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A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

Figure 5

S. haematobium egg-injected mice demonstrate Type 2 immune responses in draining lymph nodes.

Pelvic lymph nodes from egg-injected mice demonstrate persistently elevated expression of Type 2-associated cytokines (e.g. IL-4) without corresponding increases in the TH1-associated cytokines IFN-γ and IL-12. The TReg-associated marker FoxP3 is suppressed late in the experimental time course, while the immunosuppressive cytokines IL-10 and TGF-β remain unchanged. IL-17 was not detected (N.D.).

Figure 5

doi: https://doi.org/10.1371/journal.ppat.1002605.g005