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A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

Figure 2

S. haematobium egg-injected bladders develop fibrosis and urinary dysfunction.

Egg-injected bladders demonstrate histologically-apparent fibrosis within granulomata beginning at post-injection day 7 (A, Masson's trichrome stain, collagen stains blue). Later time points demonstrate increased collagen staining area and intensity (B). Total bladder soluble collagen content correlates with histologic evaluation (C). Egg-injected mice demonstrate increased urinary frequency (1 week post injection, D).

Figure 2

doi: https://doi.org/10.1371/journal.ppat.1002605.g002