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A Novel Mouse Model of Schistosoma haematobium Egg-Induced Immunopathology

Figure 1

Bladder wall injection of S. haematobium eggs results in synchronous granuloma formation.

Intramural injection of S. haematobium eggs results in rapid and localized injection site response followed by progressive expansion and consolidation over several weeks (serial micro-ultrasonography of a single representative animal, A–D; histology, E–H). Lymphoid follicles in H are marked with arrowheads. Scale bars for panels E, I, J, and L (lower right hand corner for each) are 100 microns long. Immunohistochemical characterization demonstrates central macrophage granuloma formation around injected eggs (arrows) with peripheral accumulation of other inflammatory cells (I–K, anti-CD68 brown). Epithelioid cells (activated macrophages) are indicated with arrowheads. Egg injection also induces early and sustained urothelial hyperplasia with reactive nuclear changes (L–O).

Figure 1

doi: https://doi.org/10.1371/journal.ppat.1002605.g001