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Early Priming Minimizes the Age-Related Immune Compromise of CD8⁺ T Cell Diversity and Function

Figure 2

Immunodominance hierarchies in aged mice after 1⁰ infection or 2⁰ challenge of primed-early mice.

The relative prevalence of the immunodominant D^bNP₃₆₆⁺CD8⁺ and D^bPA₂₂₄⁺CD8⁺ T cell population over the subdominant D^bPB1₇₀₃⁺CD8⁺ and K^bPB1-F2₆₂⁺CD8⁺ sets. Results are shown for (A, B) 1⁰ and (C, D) 2⁰ HK infection in (A, C) young and (B, D) aged mice. The relative contributions of particular antigen-specific CD8⁺ T cells were analysed based on total cell responses (Figure 1 for D^bNP₃₆₆⁺CD8⁺ and D^bPA₂₂₄⁺CD8⁺ and data not shown for D^bPB1₇₀₃⁺CD8⁺ and K^bPB1-F2₆₂⁺CD8⁺). Data represent the mean proportion of a particular peptide-specific CD8⁺ population. * = p<0.01 shows a difference between young and aged animals. Experimental outline as in Figure 1AB.

doi: https://doi.org/10.1371/journal.ppat.1002544.g002