Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection
Figure 1
A mitochondrial carrier protein in Legionella.
(A) Sequence alignment of LncP from L. pneumophila and Llo1924 from L. longbeachae with the ADP/ATP carrier from Bos taurus. Amino acid residues are colored red (hydrophobic), blue (acidic), magenta (basic), green (polar) and the six predicted transmembrane segments shown. Conservation is seen through the predicted transmembrane segments and in the three-fold repeated signature motif (labeled SM1a-SM1b, SM2a-SM2b, SM3a-SM3b), all of which are characteristic of all members of the mitochondrial carrier protein family [40], [41]. (B) The three-dimensional structure of the ADP/ATP carrier from B. taurus (PDB: 1OKC), with the three-fold repeated signature motif color-coded as shown in Figure 1A. The folded protein has a “height” of 46 Å and the maximum “width” dimension is 41 Å.