Th2-polarised PrP-specific Transgenic T-cells Confer Partial Protection against Murine Scrapie
Figure 3
Immunoscope analysis of TCR α-chains pairing with the BV12+ TCR β-chain.
(A) Focus on CDR3 diversity of TRAV13+ chains in naive or primed CD4+ cells from PrP+ and PrP– mice. (B) Identity between CDR3 sequences of TCR α-chains paired with the BV12+ TCR β-chain in PrP– mice and the CDR3 sequence of the original TCR α-chain identified in the T cell hybridoma. Each experiment is representative of 2 or 3 independent analyses, with a pool of at least 3 mice per test.