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Lymphoadenopathy during Lyme Borreliosis Is Caused by Spirochete Migration-Induced Specific B Cell Activation

Figure 2

Infection with host-adapted B. burgdorferi induces lymphadenopathy near the site of infection.

Lymphadenopathy of the right inguinal lymph node of C57BL/6 mice 10 days after infection via subcutaneous transplantation of small pieces of ear from B. burgdorferi-infected (A) or non-infected (B) congenic SCID mice into their right dorsal tarsal region. (C) Shown are mean cell numbers ± SD of right inguinal lymph nodes from groups of four mice per timepoint. (D) Comparison of lymph node celluarity (mean ± SD) obtained from draining lymph nodes in (C) and from the axillary lymph nodes of tick-infected mice as shown in Figure 1.

Figure 2