STAT2 Mediates Innate Immunity to Dengue Virus in the Absence of STAT1 via the Type I Interferon Receptor
Figure 4
Comparison of ISG Induction in DENV-infected mice.
Gene induction evaluated using the RT2 Profiler PCR Array (Mouse IFN-α/β Response Array; SABioscience). (A,B) Annotated gene expression of transcripts with a difference in expression of 3-fold or more over naïve (upregulation-black; downregulation-white) at 12 and 24 hours post-infection of (A) spleens isolated from wild type, STAT1−/−, STAT2−/−, and STAT1−/−/2−/− mice infected with S221, and (B) BMMs isolated from wild type, STAT1−/−, and STAT1−/−/2−/− mice infected with S221 (MOI = 5). (C, D) Gene induction in the spleen expressed as fold-increase over naïve for each strain at (C) 12 hours and (D) 24 hours post-infection. Data represent mean fold-induction of three animals per strain at each timepoint.