HIV-1 gp41 and TCRα Trans-Membrane Domains Share a Motif Exploited by the HIV Virus to Modulate T-Cell Proliferation
Figure 4
Gp41 TMD inhibit T-cell activation induced by mitogenic antibodies to CD3.
T-cells were activated with 1µg/ml anti-CD3 and APC in the presence of 50µg/ml gp41 TMD or TCRα CP and the proliferative responses were assayed. The uninhibited T-cell proliferative responses were 9103±208 cpm. The background proliferation in the absence of antigen was 257±41 cpm. The data are presented as normalized mean proliferation percentage (control, no peptide = 100%) + SD (n = 5 or more, ** p<0.01). There was no significant statistical difference between the TCRα CP and the control.