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Activation of Akt Signaling Reduces the Prevalence and Intensity of Malaria Parasite Infection and Lifespan in Anopheles stephensi Mosquitoes

Figure 6

Resistance of homozygous transgenic and non-transgenic mosquitoes to P. falciparum infection.

Homozygous transgenic (TG) mosquitoes and non-transgenic (NTG) mosquitoes were provided with an artificial bloodmeal containing P. falciparum NF54 gametocytes. Ten days after infection, the midguts were dissected and the numbers of P. falciparum oocysts were counted. A. Infection prevalence was defined as the percentage of mosquitoes that had at least one oocyst on the midgut. Homozygous transgenic mosquitoes were significantly less prone to infection (** indicates p<0.0001). B. Summary statistics of parasite data from all three experiments. Analyses were performed for each replicate separately and for the three replicates combined.

Figure 6

doi: https://doi.org/10.1371/journal.ppat.1001003.g006