Insight into the Mechanisms of Adenovirus Capsid Disassembly from Studies of Defensin Neutralization
Figure 1
Sensitivity to neutralization by alpha-defensins is AdV species specific.
HAdVs were incubated with 15 µM HD5 (A) or HNP1 (B) and assessed for infectivity on A549 cells. Data are the mean of the percent infectivity compared to control cells infected with each virus in the absence of defensin for at least three independent experiments ± SD. The upper limit for quantification of this assay is 200%. Virus serotypes are grouped by species (A–F).