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Pseudorabies Virus Infection Alters Neuronal Activity and Connectivity In Vitro

Figure 1

Elevated rates of electrical activity observed in PRV infected neurons.

(A) PRV 151 infected neurons show uniform GFP fluorescence 15 hpi. (B–E) Typical voltage traces of mock and PRV 151 infected neurons obtained using whole-cell patch recordings in current clamp. Traces from 4 different neurons are shown. −50 mV is marked by a gray dotted line for resting membrane potential comparison.

Figure 1

doi: https://doi.org/10.1371/journal.ppat.1000640.g001