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Isolation and Characterization of Adenoviruses Persistently Shed from the Gastrointestinal Tract of Non-Human Primates

Figure 1

Phylogenetic tree of adenoviruses that infect primates.

The tree was reconstructed from an alignment of the polymerase gene, using maximum likelihood under the HKY85 model of substitutions, as described in Materials and Methods. The names of simian isolates include the serotype nomenclature, the animal species of isolation (Hu: human, Ch: chimpanzee, Bo: bonobo, Go: gorilla, Cy: cynomolgus macaque, Rh: rhesus macaque), and the source of adenoviral isolation (ATCC: American Tissue Type Collection, JX: Jacksonville zoo, NI: New Iberia Research Center, MD: MD Anderson, SD: San Diego zoo, At: Atlanta zoo, LR: Little Rock zoo, BF: Buffalo zoo). Isolates that have a closely related hexon structure are referred to as variants of the same serotype (“.1” or “.2”). Names of novel sequences obtained in this study are shown in italics. Colors indicate the six species of viruses that infect higher primates (A, B, C, D, E, and F); grey is used to indicate viruses isolated from monkeys. The inset (upper left) shows the same tree with the inclusion of a tree-shrew isolate as an outgroup, after collapsing poorly supported bifurcations. Bootstrap values less than 80% or close to terminal leaves are suppressed.

Figure 1

doi: https://doi.org/10.1371/journal.ppat.1000503.g001