Immunogenicity and Protective Efficacy of a Live Attenuated H5N1 Vaccine in Nonhuman Primates
Figure 6
Viral replication in nonhuman primates.
Virus titers were determined in embryonated eggs injected with tissue homogenates on day 3 (A,B) and day 15 (C) postchallenge with AH/05 virus or BHG/05 virus. Virus was not detected in tissues harvested day 15 postchallenge from animals challenged with the BHG/05 virus (data not shown). Titers are reported for tissues from individual animals, as log10 EID50/g tissue. The dashed blue lines indicate the lower limit of detection. (D) Nasal swabs were collected from all living animals on days 2, 4, and 6 postchallenge for virus isolation in eggs.