Genetic Variation in OAS1 Is a Risk Factor for Initial Infection with West Nile Virus in Man
Figure 2
OAS1 allele dosage effect on risk of WNV infection.
(A) A plot of the estimated probabilities of being WNV-positive as a function of the number of copies of rs10774671 A allele under three different genetic models. The solid line is the additive model; the dotted line is the recessive model; the dashed line is the dominant model. Also graphed are the observed proportions of WNV cases (solid squares) along with 95% CI (solid vertical lines). (B) The allele dosage effect of the A allele for SNP rs10774671 was examined using GG homozygous individuals as a reference genotype. OR (bars) were calculated, and 95% CI shown (lines) were determined for all study subjects. Chi-square test was used to calculate P values (shown).