Advertisement

< Back to Article

BSE Case Associated with Prion Protein Gene Mutation

Figure 2

Alignment of bovine, ovine, cervid and human Prnp sequences.

(A) Nucleotide sequences. Standard single letter codes are used for nucleotides. Y = C or T; R = A or G; K = G or T; W = A or T. Boxed area indicates the 6th octapeptide-repeat of the bovine protein (U.S. BSE Alabama case and sequence AY335912). Additional Prnp sequences are as follows: AJ567986 (sheep), AF016227 (elk), Hsap M13899 (human, normal) and Hsap PRNPvar [human, variant; see [13]]. (B) Amino acid sequences. Standard IUPAC single letter codes are used for amino acids. Codon numbering refers to the most common six-copy octapeptide repeat allele for Bos Taurus. Boxed area indicates the 6th octapeptide repeat of the bovine protein [animals B14842 [4] and AY335912]. AJ567986 (sheep), AF016227 (elk), Hsap M13899 (human, normal) and Hsap PRNPvar [human, variant; see [13]] each contain a 5 octapeptide repeat region in the protein.

Figure 2

doi: https://doi.org/10.1371/journal.ppat.1000156.g002