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An Unbiased Systems Genetics Approach to Mapping Genetic Loci Modulating Susceptibility to Severe Streptococcal Sepsis

Figure 5

Functional network of genes modulating GAS QTL.

Graphical representation of the molecular relationships between differentially expressed genes, showing the central role of IL-1, IL-1rn, PTGES, and PTGES2 in modulating response to GAS sepsis and their indirect interactions with IFN-γ and IL-2 networks in modulating bacterial sepsis. Genes are represented as nodes, and the biological relationship between two nodes is represented as line, solid lines represent direct interactions, dashed lines represent indirect interactions. Oval shapes represent chemical or drug, squares represent cytokines, diamond shapes represent enzymes, concentric circles represent group of family, and triangles represent phosphates. Blue lines and arrows represent expression levels of resistant strains, while red lines and arrows represent susceptible strains expression levels. Apyrase, ATP diphosphohydorlase; ANAPC2, anaphase promoting complex subunit 2; CDC20 cell division cycle homolog 20; CXCL14, chemokine (c-x-c motif) ligand 14; ENTPD2, ectonucleoside triphosphate diphosphohydrolase 2; EDF1, endothelial differentiation-related factor 1; JUN jun oncogene; IL1A, interleukin 1 alpha; IL1RN, interleukin 1receptor antagonist; IFNG interferon gamma; IL2 interleukin2; PDCD1LG2, programmed cell death ligand 2; PTGES, prostaglandin E synthase; PTGES2, prostaglandin E synthase 2; PSMC3 proteasome (prosome, macropain) 26S subunit ATPase 3; PSMD5, proteasome (prosome, macropain) 26S subunit, non-ATPase 5; PPP2R4, protein phosphatase 2A regulatory subunit B; RBM39, RNA binding protein 39; SH2D3C, SH2 domain containing 3C; SLC6A6, solute carrier family 6; TP53 tumor protein p53; TP53RK, TP53 regulating kinase; VTCN1, V-set domain containing T cell activation inhibitor 1.

Figure 5

doi: https://doi.org/10.1371/journal.ppat.1000042.g005