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An Unbiased Systems Genetics Approach to Mapping Genetic Loci Modulating Susceptibility to Severe Streptococcal Sepsis

Figure 3

Recombinant inbred BXD strain distribution patterns at region of interest on Chr 2.

(A) Haplotype maps of the first QTL on Chr 2 between 20–34 Mb showing available BXD strains. Haplotype maps were used for in silico selection of strains for survival studies based on the strain distribution patterns, where B allele (blue bars) inherited from the resistant parent C57Bl/6J and D alleles form the susceptible parent DBA/2J, beige bars indicate strains that are heterozygous at this region, resembling an F1. Arrows indicate BXD strains 34, 51, 60, 64, 79, 94, and 100. (B) Haplotype maps of the first QTL region on Chr 2 between 20—34 Mb across BXD strains used in the population-based survival experiments showing the pattern of alleles inherited from each parent at region of interest on Chr 2. The different BXD strains are rank-ordered according to their susceptibility to GAS sepsis form susceptible to more resistant. Resistant strains show a pattern of accumulation of alleles inherited from resistant parent (B) C57Bl/6J (blue bars) while the susceptible strains show a pattern of alleles from susceptible parent (D) DBA/2J (red bars), with the exception of BXD94 strain, heterozygous (beige bars) at the QTL region. (C) Haplotype maps of the second QTL region on Chr 2 between 125—150 Mb across BXD strains used in the population-based survival experiments showing the pattern of alleles inherited from each parent at region of interest on Chr 2. The different BXD strains are rank-ordered according to their susceptibility to GAS sepsis form susceptible to more resistant. BXD genotype data set can be downloaded from www.genenetwork.org/genotypes/BXD.geno.

Figure 3

doi: https://doi.org/10.1371/journal.ppat.1000042.g003