An Unbiased Systems Genetics Approach to Mapping Genetic Loci Modulating Susceptibility to Severe Streptococcal Sepsis
(A) Interval mapping of survival (expressed as corrected relative survival index, cRSI), showing a significant QTL (based on 1000 permutation tests) on Chr 2 between 22–34 Mb with LRS of 34.2 (P≤0.0000001), and a suggestive QTL between 125–150 Mb with LRS of 12 (P≤0.001). (B) Whole genome interval mapping of GAS bacteremia using bacterial load 24 h post injection expressed as corrected log CFU/ml blood, showing two QTLs on Chr 2: first QTL between 22–34 Mb with LRS of 24.5 (P≤0.00001) and a second with LRS of 17 (P≤0.0001) between 125–150 Mb. (C) Whole genome mapping of GAS sepsis using tissue dissemination of GAS expressed as corrected log CFU/spleen with QTL between 125–150 Mb with LRS of 15 (P≤0.0001). Red line indicates significant LRS, while grey line indicates suggestive LRS. Upper x-axis shows mouse chromosomes, and lower x-axis shows physical map in mega bases, y-axis represents linkage in LRS score.