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An Unbiased Systems Genetics Approach to Mapping Genetic Loci Modulating Susceptibility to Severe Streptococcal Sepsis

Figure 1

Differential susceptibility to GAS sepsis among different BXD strains and their parental strains.

(A) Rank-ordered bar chart of survival expressed as mean values of coefficient of mean corrected relative survival indices (cRSI) across 30 different BXD strains and their parental strains (DBA/2J and C57Bl/6J) at the two extremes of the X-axis. Error bars represent the standard errors of the means. Statistical test is two-way ANOVA (with correction to covariates) P≤0.0001. Total number of mice is 489 belonging to 32 strains; number of mice used per strain is indicated. (B) Bar chart of GAS bacteremia expressed as coefficient of mean values of corrected log blood CFUs 24 h post injection (corrected log CFU/ml blood). Strains are ordered by their corrected relative survival indices with the parental strains at the two extremes of the X-axis. Error bars represent the standard errors of the means. Statistical test is two-way ANOVA (with correction to covariates) P≤0.0001. (C) Bar chart of GAS dissemination to spleen expressed as coefficient of corrected bacterial load in spleen (log CFU/spleen). Strains are ordered by their corrected relative survival indices with the parental strains at the two extremes of the X-axis. Error bars represent the standard errors of the means. Statistical test is two-way ANOVA (with correction to covariates) P≤0.0001.

Figure 1

doi: https://doi.org/10.1371/journal.ppat.1000042.g001