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Open Access
Peer-reviewed
Research Article
Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease
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Ihssane Bouybayoune ,
¶‡ These authors share first authorship on this work.
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Susanna Mantovani ,
Present address: School of Biomedical Sciences, The University of Queensland, Brisbane, Australia
¶‡ These authors share first authorship on this work.
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Federico Del Gallo ,
Present address: Department of Neurological and Movement Sciences, University of Verona, Verona, Italy
¶‡ These authors share first authorship on this work.
Affiliation Department of Health Sciences, University of Milan Medical School, Milan, Italy
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Ilaria Bertani,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Elena Restelli,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Liliana Comerio,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Laura Tapella,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Francesca Baracchi,
Affiliation Department of Health Sciences, University of Milan Medical School, Milan, Italy
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Natalia Fernández-Borges,
Affiliation CIC bioGUNE, Parque Tecnológico de Bizkaia, Derio, Spain
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Michela Mangieri,
Present address: Department of Neuropathology, Golgi Cenci Foundation, Abbiategrasso (MI), Italy
Affiliation Division of Neuropathology and Neurology, IRCCS Foundation “Carlo Besta” National Neurological Institute, Milan, Italy
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Cinzia Bisighini,
Affiliation Bio-Imaging Unit, Department of Cardiovascular Research, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Galina V. Beznoussenko,
Affiliation IFOM—FIRC Institute of Molecular Oncology, Milan, Italy
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Alessandra Paladini,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Claudia Balducci,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Edoardo Micotti,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Gianluigi Forloni,
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Joaquín Castilla,
Affiliations CIC bioGUNE, Parque Tecnológico de Bizkaia, Derio, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain
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Fabio Fiordaliso,
Affiliation Bio-Imaging Unit, Department of Cardiovascular Research, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Fabrizio Tagliavini,
Affiliation Division of Neuropathology and Neurology, IRCCS Foundation “Carlo Besta” National Neurological Institute, Milan, Italy
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Luca Imeri,
Affiliation Department of Health Sciences, University of Milan Medical School, Milan, Italy
⨯ - [ ... ],
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Roberto Chiesa
* E-mail: roberto.chiesa@marionegri.it
Affiliation Department of Neuroscience, IRCCS—“Mario Negri” Institute for Pharmacological Research, Milan, Italy
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Transgenic Fatal Familial Insomnia Mice Indicate Prion Infectivity-Independent Mechanisms of Pathogenesis and Phenotypic Expression of Disease
- Ihssane Bouybayoune,
- Susanna Mantovani,
- Federico Del Gallo,
- Ilaria Bertani,
- Elena Restelli,
- Liliana Comerio,
- Laura Tapella,
- Francesca Baracchi,
- Natalia Fernández-Borges,
- Michela Mangieri
- Published: April 16, 2015
- https://doi.org/10.1371/journal.ppat.1004796