Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

Amit Singh; David K. Crossman; Deborah Mai; Loni Guidry; Martin I. Voskuil; Matthew B. Renfrow; Adrie J. C. Steyn

doi:10.1371/journal.ppat.1000545

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Peer-reviewed

Research Article

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

Amit Singh,

Affiliation Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
David K. Crossman,

Affiliation Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Deborah Mai,

Affiliation Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Loni Guidry,

Affiliation Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Martin I. Voskuil,

Affiliation Department of Microbiology, University of Colorado Denver, School of Medicine, Aurora, Colorado, United States of America
⨯
Matthew B. Renfrow,

Affiliation Department of Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Adrie J. C. Steyn

* E-mail: asteyn@uab.edu

Affiliation Department of Microbiology, Centers for Free Radical Biology, AIDS Research, and Emerging Infections and Emergency Preparedness, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯

Mycobacterium tuberculosis WhiB3 Maintains Redox Homeostasis by Regulating Virulence Lipid Anabolism to Modulate Macrophage Response

Amit Singh,
David K. Crossman,
Deborah Mai,
Loni Guidry,
Martin I. Voskuil,
Matthew B. Renfrow,
Adrie J. C. Steyn

Published: August 14, 2009
https://doi.org/10.1371/journal.ppat.1000545

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23 Aug 2009
19:12 GMT
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Posted by viks on 23 Aug 2009 at 19:12 GMT

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Mycobacterium tuberculosis
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Lipids
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Oxidation-reduction reactions
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Macrophages
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Propionates
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Biosynthesis
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Lipid analysis
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