A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection

Katharine N. Bossart; Zhongyu Zhu; Deborah Middleton; Jessica Klippel; Gary Crameri; John Bingham; Jennifer A. McEachern; Diane Green; Timothy J. Hancock; Yee-Peng Chan; Andrew C. Hickey; Dimiter S. Dimitrov; Lin-Fa Wang; Christopher C. Broder

doi:10.1371/journal.ppat.1000642

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Open Access

Peer-reviewed

Research Article

A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection

Katharine N. Bossart ,

* E-mail: kbossart@bu.edu (KNB); cbroder@usuhs.mil (CCB)

Current address: Department of Microbiology and National Emerging Infectious Diseases Laboratories Institute, Boston University School of Medicine, Boston, Massachusetts, United States of America

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Zhongyu Zhu,

Affiliations Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America, BRP, SAIC-Frederick, Inc., NCI-Frederick, Frederick, Maryland, United States of America
⨯
Deborah Middleton,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Jessica Klippel,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Gary Crameri,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
John Bingham,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Jennifer A. McEachern,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Diane Green,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Timothy J. Hancock,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Yee-Peng Chan,

Affiliation Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America
⨯
Andrew C. Hickey,

Affiliation Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America
⨯
Dimiter S. Dimitrov,

Affiliation Protein Interactions Group, CCRNP, CCR, NCI-Frederick, NIH, Frederick, Maryland, United States of America
⨯
Lin-Fa Wang,

Affiliation CSIRO Livestock Industries, Australian Animal Health Laboratory, Geelong, Victoria, Australia
⨯
Christopher C. Broder

* E-mail: kbossart@bu.edu (KNB); cbroder@usuhs.mil (CCB)

Affiliation Department of Microbiology and Immunology, Uniformed Services University, Bethesda, Maryland, United States of America
⨯

A Neutralizing Human Monoclonal Antibody Protects against Lethal Disease in a New Ferret Model of Acute Nipah Virus Infection

Katharine N. Bossart,
Zhongyu Zhu,
Deborah Middleton,
Jessica Klippel,
Gary Crameri,
John Bingham,
Jennifer A. McEachern,
Diane Green,
Timothy J. Hancock,
Yee-Peng Chan

Published: October 30, 2009
https://doi.org/10.1371/journal.ppat.1000642

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01 Dec 2009
19:53 GMT
Most Recent

Nipah model on TWiV Posted by Profvrr on 01 Dec 2009 at 19:53 GMT

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Ferrets
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Respiratory infections
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Nipah virus
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Henipavirus
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Blood
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