Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

Ou Zhang; Mattie C. Wilson; Wei Xu; Fong-Fu Hsu; John Turk; F. Matthew Kuhlmann; Yingwei Wang; Lynn Soong; Phillip Key; Stephen M. Beverley; Kai Zhang

doi:10.1371/journal.ppat.1000692

Loading metrics

Open Access

Peer-reviewed

Research Article

Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

Ou Zhang,

Affiliation Department of Biological Sciences, Texas Tech University, Lubbock, Texas, United States of America
⨯
Mattie C. Wilson,

Affiliation Department of Biological Sciences, Texas Tech University, Lubbock, Texas, United States of America
⨯
Wei Xu,

Affiliation Department of Biological Sciences, Texas Tech University, Lubbock, Texas, United States of America
⨯
Fong-Fu Hsu,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
John Turk,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
F. Matthew Kuhlmann,

Affiliation Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Yingwei Wang,

Affiliation Department of Microbiology and Immunology, Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Lynn Soong,

Affiliation Department of Microbiology and Immunology, Department of Pathology, The University of Texas Medical Branch, Galveston, Texas, United States of America
⨯
Phillip Key,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Stephen M. Beverley,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Kai Zhang

* E-mail: kai.zhang@ttu.edu

Affiliation Department of Biological Sciences, Texas Tech University, Lubbock, Texas, United States of America
⨯

Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

Ou Zhang,
Mattie C. Wilson,
Wei Xu,
Fong-Fu Hsu,
John Turk,
F. Matthew Kuhlmann,
Yingwei Wang,
Lynn Soong,
Phillip Key,
Stephen M. Beverley

Published: December 11, 2009
https://doi.org/10.1371/journal.ppat.1000692

Reader Comments

Post a new comment on this article

Publisher's Note: Correction to Figure 3

Posted by PLOS_Pathogens on 23 Dec 2009 at 14:11 GMT

Figure 3
ISCL is required for the hydrolysis of sphingomyelin and IPC.
http://plospathogens.org/article/info:doi/10.1371/journal.ppat.1000692#ppat-1000692-g003

Panels C,D,E, and F were incorrectly labeled in Figure 3. Panels C and E should be reversed, as should panels D and F. The corrected figure can be found here: http://www.plospathogens.org/corrections/ppat.1000692.g003.cn.tif

No competing interests declared.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Promastigotes
Is the Subject Area "Promastigotes" applicable to this article?

Thanks for your feedback.
Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Leishmania
Is the Subject Area "Leishmania" applicable to this article?

Thanks for your feedback.
Amastigotes
Is the Subject Area "Amastigotes" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Lipids
Is the Subject Area "Lipids" applicable to this article?

Thanks for your feedback.
Thin-layer chromatography
Is the Subject Area "Thin-layer chromatography" applicable to this article?

Thanks for your feedback.
Hydrolysis
Is the Subject Area "Hydrolysis" applicable to this article?

Thanks for your feedback.

Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

Degradation of Host Sphingomyelin Is Essential for Leishmania Virulence

Reader Comments

Post Your Discussion Comment

Why should this posting be reviewed?

Thank You!

Publisher's Note: Correction to Figure 3

Posted by PLOS_Pathogens on 23 Dec 2009 at 14:11 GMT