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Confounding?..

Posted by madbat on 29 Nov 2012 at 16:42 GMT

The paper is interesting, and the virus is novel. The only sure thing.

To me, at this point there are too many speculations and conjectures regarding association of this virus with the disease outbreak. Still can be a confounding. As authors fairly mentioned, there are still quite many cases of VHS with unknown etiology (and negative for this novel virus).

Too pity that the virus could not be isolated (perhaps because of the VNA presence?) and characterized more rigorously.

More doubts on the Di-Ma transmission, possible vectors etc...

I would prefer to see more fair and unbiased discussion.

No competing interests declared.

RE: Confounding?..

cychiu98 replied to madbat on 29 Nov 2012 at 20:13 GMT

Efforts are underway in central Africa to track down the origin of this virus. We are also working on generation of infectious virus directly from cloned cDNA, as described previously for other rhabdoviruses such as rabies (Schnell, et al., 1994, EMBO J 13(18):4195-203), which will permit more rigorous characterization.

No competing interests declared.