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Ankyrin receptor

Posted by Gilmer on 16 Dec 2010 at 11:20 GMT

I think this paper is very informative and should be looked in a different way with the ankyrins story. In insects and mammals, ankyrins regulate innate responses (NFKB). Here, depletion of ANK may also be interpreted by an increased cellular response to "infection, stress, ..." (by the release of plant NFKB-LIKE protein). On the other hand, ANK over expression effect could be seen as an efficient repression of the transcription activation mediated by "NFKB-Like". In this situation, this will lead to a better infection, seen by authors.
Authour could verify this by the use of other pathogens (virus, bacteria, ...). ANK overexpressor should be more sensitive. Polydnaviruses use expression of vANK (that do not contain PEST sequence) to inhibit innate response in insects.
MP-Ank interaction may acts as a stabilisator of plant NFKB/ANK leading to a reduced innate response.
With the hope that this will help the authors, best wishes
David Gilmer

No competing interests declared.

RE: Ankyrin receptor

UekiShoko replied to Gilmer on 17 Dec 2010 at 22:30 GMT

Thank you for the suggestion, it is interesting point. One thing is, when we tested the viral accumulation in the protoplasts obtained from the same transgenic plants, we did not see any difference in infection process (i,e, speed of accumulation of the viral RNA) in the cells depending on the ANK level, and this is the base for our concluding that the MP-ANK interactin is important for the movement/PD gating. At the same time, the involvement of ANK in desease resistance is known to date, and it is interesting to pursure the point, too. I appreciate your comment.
Shoko Ueki

No competing interests declared.