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closeCited evidence does not support a role for NSP1 in rotavirus inhibition of STAT 1 nuclear accumulation
Posted by bcoulson on 29 Jan 2013 at 04:35 GMT
We originally reported our discovery of the ability of rotaviruses to inhibit the nuclear accumulation of STAT 1 and STAT 2 in 2009 [1]. In this 2013 review by M. Arnold and associates, it is stated at the bottom of column 1 on page 5 that this suppression of STAT 1 signalling we originally reported would seem likely to be mediated by the rotavirus non-structural protein NSP1. However, our experiments showed that NSP1 expressed alone did not affect IFN-induced gene expression in a reporter system [1], and no other reports on this subject have since been published. Thus, the published evidence does not support a role for NSP1 in the rotavirus inhibition of STAT 1 nuclear accumulation that was originally observed.
We suggest that the text be amended in a manner similar to the following:
Also worth noting is a study showing that rotavirus suppresses IFN signalling by inhibiting STAT1 nuclear accumulation [58]. The viral mediator of this effect has not been identified, although NSP1 does not appear to have a major role based on the studies reported to date [58].
1. Holloway G, Truong TT, Coulson BS (2009) Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB. J Virol 83: 4942-4951.